Hydroxypropyl Beta Cyclodextrin (HP-β-CD) is an etherified derivative of Beta Cyclodextrin widely used as a pharmaceutical excipient and solubility enhancer. It improves the solubility, stability and bioavailability of poorly water-soluble drugs, modifys or controls their release rate. HP-β-CD is widely used in cosmetic, bodybuilding and pharmaceuticals.
What is hydroxypropyl beta cyclodextrin?
Hydroxypropyl Beta Cyclodextrin (HP-β-CD) is an etherified derivative of Beta Cyclodextrin with significantly improved water solubility and safety. As a solubilizing agent, Hydroxypropyl Beta Cyclodextrin (HP-β-CD) forms inclusion complexes with active ingredients, which enhances the dissolution and solubility of poorly water-soluble and lipophilic compounds.
HP-β-CD helps ‘carry’ active ingredients in a stable and more soluble form, which makes it essential in modern formulation development.
What does hydroxypropyl beta cyclodextrin do?
Hydroxypropyl Beta Cyclodextrin has a cavity as binding sites for substrates or guest molecules,which is used for constructing various supramolecular structures, especially functionalized supramolecular aggregates.
Applications of Hydroxypropyl Beta Cyclodextrin
Pharmaceutical Applications
- Injection formulations
- Oral drugs
- Ophthalmic formulations
- Nasal delivery
- Topical preparations
Cosmetic Applications
- Encapsulation of fragrances
- Stabilization of vitamins
- Essential oils
- Preventing oxidation of active ingredients
Food Applications
- Flavor protection
- Odor masking
- Solubility enhancement
Hydroxypropyl Beta Cyclodextrin vs Beta Cyclodextrin
| Feature | HP-β-CD | Beta Cyclodextrin |
| Solubility | higher | lower |
| Toxicity | lower | higher |
| Injection use | Yes | limited |
| Inclusion efficiency | better | standard |
Is Hydroxypropyl Beta Cyclodextrin Safe?
Yes,Hydroxypropyl Beta Cyclodextrin is considered safe. In some drugs, Hydroxypropyl Beta Cyclodextrin can slow down the release of certain ingredients and protect the human body. It is also approved by DMF,CEP,CDE.
How to choose a reliable HPβCD supplier?
A reliable Hydroxypropyl Beta Cyclodextrin supplier should be evaluated based on production capacity, product quality consistency, regulatory qualifications, and export experience. HSH Chemical supplies HP-β-CD in technical, injection, oral, and cosmetic grade to meet different application requirements. Our production system is certified under ISO 9001:2015, AAA credit enterprise,TÜV certification.
With almost ten years exporting experience, HSH Chemical provides stable supply, professional export services, and full technical documentation support for cyclodextrin derivatives. We are committed to delivering high-quality cyclodextrin derivatives and long-term value to global pharmaceutical, cosmetic, and food industry partners.
